Diastolic dysfunction in sickle cell
نویسندگان
چکیده
منابع مشابه
Diastolic dysfunction in sickle cell.
In adults with sickle cell disease (SCD), echocardiographic evidence of diastolic dysfunction is an independent risk factor for death that is additive to pulmonary hypertension. In this issue of Blood, Johnson and colleagues describe echocardiography and polysomnography results from 44 children with SCD. Because their echocardiograms were ordered for clinical indications, potentially biasing to...
متن کاملSickle-cell Anemia and Latent Diastolic Dysfunction: Echocardiographic Alterations
Sickle-cell anemia (SCA) is a disease that can cause systemic complications, such as multiple organ dysfunction due to vaso-occlusion and endothelial activation. The genetic cause of the disease is a substitution of the amino acid glutamic acid for valine in the position 6 of the beta globin chain1. Stress factors in the vascular microenvironment (cellular dehydration, hypoxemia, increased corp...
متن کاملDiastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.
OBJECTIVES The goal of this study was to characterize left ventricular diastolic function in the sickle cell disease (SCD) population and to relate echocardiographic measures of dysfunction with pulmonary hypertension and mortality. BACKGROUND Pulmonary hypertension has been identified as a predictor of death in the adult SCD population. Although diastolic dysfunction is also observed in this...
متن کاملDiastolic Dysfunction Is an Independent Risk Factor for Death in Patients With Sickle Cell Disease
Results Diastolic dysfunction was present in 18% of patients. A combination of diastolic dysfunction and pulmonary hypertension was present in 11% of patients, and diastolic dysfunction accounted for only 10% to 20% of the variability in tricuspid regurgitation (TR) jet velocity. Diastolic dysfunction, as reflected by a low E/A ratio, was associated with mortality with a risk ratio of 3.5 (95% ...
متن کاملRenal tubular dysfunction in sickle cell disease.
BACKGROUND/AIMS Kidney abnormalities are one of the main chronic complications of sickle cell disease (SCD). The aim of this study is to investigate the occurrence of renal tubular abnormalities among patients with SCD. METHODS This is a prospective study with 26 SCD adult patients in Brazil. Urinary acidification and concentration tests were performed using calcium chloride (CaCl2), after a ...
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ژورنال
عنوان ژورنال: Blood
سال: 2010
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2010-04-279919